Ziprasidone drug administration

Eleven days after the administration of a single 20-mg oral dose of C-labeled ziprasidone (517) to human volunteers, 20% was recovered in the urine and 66%in the feces. The absorption was rapid and the for free drug and metabolites occurred at 2-6 h postdose. The mean peak serum concentration of unchanged ziprasidone was 45 ng/mL with a mean area under the curve (AUC) cf 336 ng/h/ mL. On the basis of AUC values, approximately 46% of the circulating radioactivity was attributed to unmetabolized ziprasidone. Less than 5% of the administered dose was excreted as unchanged drug. 

Psychiatric The incidence of suicide-related events in patients with schizophrenia or bipolar disorder taking aripiprazole has been studied using administrative data from three US sources [65 "]. Suicide attempts and death by suicide were assessed in patients aged at least 18 years. Among 20489 antipsychotic drug users (8985 patient-years), unadjusted suicide event rates per 1000 patient-years were 21 for aripiprazole 24 for olanzapine 32 for quetiapine 20 for risperidone and 49 for ziprasidone. Compared with current users of the other antipsychotic... 

---