Zinc-containing motifs binding

Two zinc-containing motifs in the glucocorticoid receptor form one DNA-binding domain... 

Several different groups of zinc-containing motifs have been observed The classic zinc fingers bind to DNA in tandem along the major groove... 

Sukegawa, J., and Blobel, G. (1993). A nuclear pore complex protein that contains zinc finger motifs, binds DNA and faces the nucleoplasm. Cell (Cambridge, Mass.) 72, 29-38. 

Figure 2. Structural and functional domains of PARP-1. PARP-1 has a highly conserved structural and functional organization including (1) an N-terminal DNA binding domain with two Cys-Cys-His-Cys zinc finger motifs (FI and Fll), (2) a nuclear localization signal (NLS), (3) a central automodification domain containing a BRCT ( BRCAl C-terminus-like ) protein-protein interaction motif, and (4) a C-terminal catalytic domain with a contiguous 50 amino acid sequence, the PARP signature motif, that forms the active site...

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