Zinacef - Cefuroxime

Zinacef (cefuroxime) labeling, in Physicians Desk Reference, 54th ed. Montvale, NJ Medical Economics 2005. p. 1678. 

First generation-cephalexin (Keflex), cefazolin (Ancef), cephapirin (Cefadyl) Second generation-cefaclor (Cedor), cefoxitin (Mefoxin), cefuroxime (Zinacef)... 

Antibiotics based on a related ring system, termed the cephems (figure 23.2), are highly useful. Here the five-membered ring has been expanded to six and the double bond of the penems retained. These are the cephalosporins and include such important antibiotics as cephalothin (Keflin), cefazolin (Ancef), cephalexin (Keflex), cefamandole (Cefam), cefuroxime (Zinacef), cefeclor (Ceclor) and cefoxitin (Mefoxin). 

The cephalosporins distribute in satisfactory concentrations to most tissues except the central nervous system. Only cefepime, cefuroxime (Zinacef), cefotaxime (Claforan), ceftriaxone Rocephin), and ceftazidime (Eortaz) achieve therapeutic concentrations in cerebrospinal fluid. Cefotaxime and ceftriaxone are antibiotics of first choice for the empirical treatment of brain abscess and meningitis. 

Oral 250, 500 mg tablets powder to reconstitute 125, 250 mg/5 mL suspension Cefuroxime (generic, Ceftin, Kefurox, Zinacef)... 

Cefuroxime Kefurox, Zinacef IV, IM associated with acute bronchitis, urinary tract infections, skin infections, Lyme disease... 

Cefuroxime (Ceftin, Zinacef) Protein-Binding 50% Half-Life 1.5-2 hours PO IM/IV 250-500 mg 0.75-1.5 g Every 12 hours Every 8 hours... 

Perhaps one of the most successful second-generation cephalosporins is cefiiroxime (Zinacef ) (Fig. 22.27). Cefiiroxime is stable to bacterial P-lactamases and can be administered either parenterally or orally as its acetoxy-ethoxy ester cefuroxime axetil (Zinnat ). 

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