Yingzhaosu antimalarial activity

All the reactions reported in this section deal with modification of substituents of dioxocins, analogues of the natural antimalarial agent yingzhaosu A, possessing antimalarial activity or utilized in the total synthesis of the natural product. 

A further support to the antimalarial potential of peroxides may be derived from yingzhaosu A. (39), a sesquiterpene peroxide isolated from Artabotrys undnatus [76]. The structure-activity relationship in the analogues of yingzhaosu has also been studied. The promising members of this class are Ro-40-6772, Ro-41-3823 and Ro-42-1611, which are under detailed biological evaluations [62]. 

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