Xylose three dimensional structure

Knowledge of the three-dimensional structure of an enzyme is the basis for understanding its substrate specificity. Thus, the E. coli Rhal was crystallized and its X-ray crystal structure was solved in collaboration with I. Korndorfer [22]. The enzyme is a tight tetramer of four (P/a)g barrels, with structural similarity to xylose isomerase (Eig. 2.2.5.3). The structures of complexes of rhamnose isomerase with the inhibitor L-rhamnitol and the natural substrate L-rhamnose were... 

D-Xylose isomerase catalyzes the interconversion between D-xylose and D-xylulose (Fig. 17-21). Since this enzyme acts on D-glucose to produce D-fructose, it is often referred to as glucose isomerase (Fig. 17-21). The isomerization of glucose to fructose by this enzyme is a very important process for the industrial production of high fructose com syrup. This enzyme is also applicable to the synthesis of many aldoses and ketoses because of its wide substrate specificity. The enzyme gene has been cloned from various microorganisms, and the enzyme has been overexpressed, purified, and characterized. Their three dimensional structures have also been determined I203-206. ... 

Fig. 42 The three-dimensional structures of the two observed confonners of o-D-xylose showing the intramolecular hydrogen bond arrangements. (Frran [223])...

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