Xylometazoline hydrochloride

Xylometazoline hydrochloride 0.05%, Purified water, sorbitol, and mono and dibasic sodium phosphates. 

In the case of xylometazoline hydrochloride, imine hydrolysis chemistry occurs to open the 4,5-dihydro-lH-imidazole ring (Fig. 55) (90). Similar degradation chemistry is observed for the following APIs flurazepam hydrochloride (91), clorazepate dipotassium (92), clonazepam (93), methaqualone (94), chlordiazepoxide, and oxazepam (18). 

Infra-red Spectrum. Principal peaks at wavenumbers 1602,1253, 1298, 871,1237, 800 (xylometazoline hydrochloride, KBr disk). 

Xylometazoline Hydrochloride 310d Betaine 330d Methylthiouracil... 

Eye drops are available containing an antihistamine, antazoline sulphate 0.5%, and xylometazoline hydrochloride 0.05%. The latter has vasoconstrictor action and is included as a conjunctival decongestant. This preparation can be used for the short-term treatment of hayfever symptoms, but prolonged use may raise intraocular pressure and precipitate glaucoma. The drops are used twice or three times daily and are suitable for children from 5 years of age. 

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