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Xylocaine, 4-component reaction

Hulme C, Gore V (2003) Multi-component reactions emerging chemistry in drug discover. From xylocain to crixivan. Curr Med Chem 10 51-80... [Pg.33]

Heteroeyeles 41(5) 1045-1049. doi 10.3987/COM-95-7041 Hulme C, Gore V (2003) Multi-component reactions emerging chemistry in drug discovery from Xylocain to Crixivan. Curr Med Chem 10(l) 51-80. doi 10.2174/0929867033368600 Hulme C, Dietrieh J (2009) Emerging molecular diversity from the intra-molecular Ugi reaction iterative efBcieney in medicinal chemistry. J Mol Divers 13(2) 195-207. doi 10.1007/sll030-009-9111-6... [Pg.414]

Scheme 8.10 Three-component Ugi reaction in the synthesis of xylocaine 28... Scheme 8.10 Three-component Ugi reaction in the synthesis of xylocaine 28...
Ugi reactions are characterized by the use of isocyanides as a strong electrophilic component. In the next example, formaldehyde, dimethylamine and 2,5-dimethylphenylisocyanide are combined in one step to xylocaine 11, an important local anesthetic (Scheme 6.3) [8]. [Pg.145]

See other pages where Xylocaine, 4-component reaction is mentioned: [Pg.7]    [Pg.13]    [Pg.424]   
See also in sourсe #XX -- [ Pg.7 ]



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