Xanthone Dimers and Heterodimers

In terms of bioactivity, monodictysin B was shown to inhibit cytochrome P450 1A with an /C50 value of 3.0 iM. Both monodicysins B and C were shown to effect the induction of NAD(P)H quinone reductase (QR) in Hepa cells. The modulation of Phase II detoxifying enzymes such as QR is important for both the metaboUsm and excretion of carcinogens, and this target enzyme is employed frequently in the study of potential cancer chemopreventive agents 637) (640). 

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Xanthone dimers and heterodimers possess increasingly complex and interesting structures, and in many cases have shown specific and selective biological properties. They include acremoxanthones A-C (347, 989), vinaxanthone (991), and xanthofulvin (1004). 

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