X-ray Structure Analysis of ACE

For the first time, it was possible in 2003 to determine the structure of human testicular ACE by means of high-resolution X-ray analysis (Fig. 5.17). [18, 19] There are two isoforms of ACE the somatic form, a glycoprotein with a chain of 1,277 amino acids, and the ACE of germ cells this is smaller and comprises 701 amino acids. The somatic ACE contains two homologous domains, the N- and C-domains, the latter of which being identical with the testicular ACE. This domain is responsible for the regulation of blood pressure. 

17 TheACE-lisinopril complex. The structure consists of two sub-domains (shown in turquoise and violet) it contains two chloride ions (red), and in the catalytic centre the zinc ion (green) and the inhibitor lisinopril (brown). 

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