Wyeth Research

Department of Chemistry and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, NY, 10965, USA e-mail bikkerj wyeth.com... 

Chemical and Screening Sciences, Wyeth Research, Pearl River, NY, USA... 

Wyeth Research, Discovery Neuroscience, CN8000, Princeton, NJ 08543, USA Wyeth Research, Chemical and Screening Sciences, CN8000, Princeton, NJ 08543, USA... 

Andrew Dorner Wyeth Research, Andover, Maryland, U.S. 

Joanne Killinger Wyeth Research, Chazy, New York, U.S. 

Ronald A. Salerno Worldwide Regulatory Affairs, Wyeth Research, St. Davids, Pennsylvania, U.S. 

Syracuse University University of Louisville Wyeth Research Georgia Institute of Technology University of Massachusetts-Dartmouth Lawrence Berkeley National Laboratory University of Southern California University of Wisconsin-Stout... 

Because the T790M mutation affects the ability of reversible TKIs to bind to EGFR, it follows that irreversible inhibitors may circumvent this problem. Irreversible EGFR inhibitors such as HKI-272, HKI-357, and a compound developed by Wyeth Research, EKB-569, have shown some early efficacy (81,91,92). These compounds form covalent bonds with the EGFR protein at a distinct cysteine residue C773, within the kinase... 

The author wishes to thank Dr. Sharon Pan, Dr. Marc Tesconi, and Dr. Yung-Cheng Chen (Wyeth Research) for their contributions to the preparation of this manuscript. 

Saranjit Singh / National Institute of Pharmaceutical Education and Research, Punjab, India Shailesh K. Singh / Wyeth Research, Pearl River, New York, U.S.A. 

Margaret Davis, Biotransformation Division, Department of Drug Safety and Metabolism, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426... 

Marshall M. Siegel, Wyeth Research, Discovery Analytical Chemistry, 401 N. Middletown Road, Building 222, Room 1043, Pearl River, NY 10965... 

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