Woodward, Scott

Table 9.2 Correlation table in UV/Visible spectroscopy. Fieser-Woodward-Scott rules for the calculation of the position of the absorption maxima for enones and dienones (margin 3nm).

Baldomero M. Olivera, David R. Hillyard, Jean Riviei, Scott Woodward, William R. Gray, Gloria Corpuz, and Lourdes J. Cruz ... 

Structural analysis from electronic spectra yields little information because of their relative simplicity. In the 1940s, however, before the advent of more powerful identification techniques, UV/VIS visible spectroscopy was used for structural identification. The study of a great number of spectra of various molecules has revealed correlations between structures and the positions of absorption maxima. The most widely known empirical rules, due to Woodward, Fieser and Scott, involve unsaturated carbonyls, dienes and steroids. Using incremental tables based on various factors and structural features, it is possible to predict the position of the n —> n absorption bands in these conjugated systems (Table 11.3). Agreement between the calculated values and the experimentally determined position of absorption bands is usually good, as can been seen by the following four examples ... 

Scott CD, Davison BH, Scott TC, Woodward J, Dees C, Rothrock DS (1994) Appl Biochem Biotechnol 45/46 641... 

Brigham Young researcher Scott Woodward takes a bone sample for carbon-14 dating at an archeological site In Egypt. 

Within the past few years numerous syntheses of colchicine (or its simple derivatives) and desacetamidocolchicine (which can readily be reconverted to colchicine) have been published. A wide variety of approaches have been employed, which in terms of the order of formation of rings A, B, and C may be summarized as (1) A->-AB->ABC, and (2) A->-AC->ABC. The syntheses of van Tamelen, Eschenmoser, Woodward, and Martel are variations of the first approach, while the second route, in different modifications, has been utilized by Nakamura and Scott. Chemical ground has been broken in several of these syntheses, illustrating again the fact that new chemical ideas are often gained in the course of constructing complicated natural products. 

Spada, C.S., Woodward, D.E, Krauss, A.H-P, Neives, A.L., Wheeler, LA., Scott, D., and Sachs, G. (2002). Bimatoprost and PGF2-alpha selectively stimulate calcium signals in different cat iris sphincter cells. Ebcp. Eye Res., 12, Suppl. 2, 78. 

Strategy A-B-C 1 Banwell Strategy A-B-C 2 Roussel, Woodward Strategy A-B-C 3 Scott, van Tamelen Strategy A-B-C 4 Eschenmoser Strategy A-B-C 5 Cha Strategy A-(B + C) 1 Schmalz Strategy A-(B + C) 2 Evans... 

From R. B. Woodward, /. Am. Cliem. Soc., 63,1123 (1941) 64,72,76 (1942) L. F. Fieser and M. Fieser, Natural Products Related to Phenanthrene, Reinhold, New York, 1949 A. I. Scott, Interpretation of the UV Spectra of Natural Products, Pergamon Press, New York, 1964. Reproduced with permission from J. B. Lambert et al.. Organic Structural Spectroscopy. Copyright 1998 Prentice Hall, Inc. 

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