Wolff-Kichner reduction

The formation of hydrazones from the corresponding carbonyl compounds has been accomplished initially in toluene [79]. The treatment of hydrazone with alkali (KOH) accomplishes Wolff-Kichner reduction that proceeds in good yield under... 

Wittig reaction, 2 64-65, 19 65 Wobbe Number, 12 378-379 Wohl-Aue synthesis, 2 787 Wohlwill refining process, 22 647 Wolff-Chaikoff effect, 14 373 Wolff-Kichner reduction, 13 569-570,... 

The formation of hydrazones from the corresponding carbonyl compounds has been accomplished initially in toluene [88]. Treatment of hydrazone with alkali (KOH) accomplishes Wolff-Kichner reduction that proceeds in good yield under MW irradiation conditions [89]. Varma and Kocevar s group have shown that solvent-free and catalyst-free reaction of hydrazines with carbonyl compounds is possible on MW irradiation (Scheme 8.29) [90]. Interestingly, the general reaction proceeds smoothly even for solid reactants and is completed below the melting points of the two reactants, possibly via the formation of a eutectic. The reactions have been conducted in a household MW oven and the control experiments were conducted concurrently in separate open beakers the reactions can be essentially followed by visual observation when a melt is obtained [91]. 

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See also in sourсe #XX -- [ ]

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