Wittig Coupling of the Northern and Southern Hemispheres

Extension of the in situ CaH.2 method to the Wittig reaction of more complex model compounds, on ever smaller quantities of material, led progressively to the formation of C16-C39 (CDE), C1-C39 (ABCDE) and 

Exposure of 76 to HF in H20/MeCN for 20 hours was followed by a short microscale flash column. Analysis by H NMR spectroscopy (500 MHz, CD3CN, 16 hours) of the global deprotection product showed it to be a complex mixture, however there were some encouraging signals. Purification of this mixture was attempted by HPLC-MS (25 75 

Growth Inhibition Against Human Cancer Cell Lines 

The spongi journey was at times a bumpy and frustrating one, but nevertheless wholly rewarding to all involved. Once more, Charles Dickens A Tale of Two Cities has a poignant passage in this regard  

The work described in this chapter would not have been possible without the tireless efforts and experimental skill of the following people (the spongi team) Jose Luis Acena, Jordi Bach, David Chen, Karl Gibson, Andrew Hodgson, Linda Keown, Roger Norcross, Renata Oballa, Thomas Trieselmann, Debra Wallace. 

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