Wipke

The use of computers for the design of chemical syntheses was first demonstrated by Corey and Wipke in 1969 with their program OCCS [30]. The successor to OCCS, LHASA [31], is generally considered to be the first synthon-based system. Its development is still going on. Currently, three groups are working on LHASA, one at Harvard University, USA [32], one at the University of Leeds, UK [33], and... 

Computer-Assisted Organic Synthesis W. T. Wipke, W. J. Howe, Eds., ACS, Washington (1977). 

The reaction flow-charts of Part Two, and indeed all chemical formulae which appear in this book, were generated by computer. The program used for these drawings was ChemDraw adapted for the Macintosh personal computer by Mr. Stewart Rubenstein of these Laboratories from the molecular graphics computer program developed by our group at Harvard in the 1960 s (E. J. Corey and W. T. Wipke, Science, 1969,166, 178-192) and subsequently refined. 

Corey EJ, Wipke WT, Cramer RD HI, Howe WJ. Computer-assisted synthetic analysis. Facile man-machine communication of chemical structure by interactive computer graphics. J Am Chem Soc 1972 94 421-30. 

Wipke, WT, Gund P. Congestion. Conformation-dependent measure of steric environment. Derivation and application in stereoselective addition to unsaturated carbon./Am Chem Soc 1974 96 299-301. 

Gund P, Grabowski EJJ, Smith, GM, Andose ID, Rhodes JB, Wipke WT. In Olson EC, Christoffersen RE, editors. Computer-assisted drug design. ACS Symposium Series 112. Washington, DC American Chemical Society, 1979. p. 526-51. 

Wipke BT, Wang Z, Nagengast W, Reichert DE, Allen PM. Staging the initiation of autoantibody-induced arthritis a critical role for immune complexes. J Immunol 2004 172(12) 7694-7702. 

In 1969 Corey and Wipke [7] reported the program OCSS (Organic Chemical Simulation of Synthesis) which was the precursor of one of the most powerful programs known at present which has been named LHASA (the acronym of Logic and Heuristics Applied to Synthetic Analysis) [5b] [8]. Since then, different... 

WIPKE AND HAHN Analogy and Intelligence in Model Building... 

Wipke, W. T. "Computer-Assisted Three-Dimensional Synthetic... 

Corey, E. J. Wipke, W. T. "Computer-Assisted Design of Complex Molecular Syntheses". Science 1969t 166, 178. 

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