Whole-Genome Approaches

Integrating In Vitro Data to Model Toxicity Potential 

The in vitro screening approach measures direct mechanistic links between chemical interactions with key targets and the downstream effects of perturbing the related molecular pathways. By using current knowledge ofthe molecular basis of diseases, one can enrich an assay set to probe targets in key disease-related pathways and thereby develop predictive models in a more hypothesis-driven manner. 

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The next paragraphs will first summarize previous pharmacogenetic studies (mostly on antidepressant drugs) and then expand on the techniques available for whole genome approaches. 

Todd JA. Genetic analysis of type 1 diabetes using whole genome approaches. Proc Natl Acad Sci U S A 1995 92 8560-5. 

The knowledge of the sequence of the human genome, which has been publicly available to all researchers since February 2001 (Lander et al. 2001 Venter et al. 2001), has dramatically changed the possibilities for genetic approaches. It is now possible to screen the whole genome in a hypothesis-... 

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