Whole body radiography

Bergman, K. (1984) Application and results of whole-body radiography in distribution studies of organic solvlents. Crit. Rev. Toxicol., 12, 59-119... 

The distribution of the substance in the body is often studied with substances that have carbon-14 as a radioactive label in the molecule. The labeled substance must be specifically S3mthesized, but it allows a direct visualization of the distribution in the animal body. In a process called whole body radiography, thin slices of the dead deep-firozen animal are prepared and scanned for distribution of radioactivity. Images of the various two-dimensional slices are then combined to give a three-dimensional pic-tvire. In a parallel experiment, the target organs are isolated and extracted with solvents. The extracts are used to isolate and identify the metabohtes. 

Durand et al. (2002) M. edulis 1 ppb BaP (7 days/subtidtil, 14 days/intertidal tottil experiment duration) LPO (mantle) Increased retention of BtiP in mantle and slower depuration of whole body burden in intertidal Liquid scintillation radiography of C... 

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