White’s total synthesis

The glycosylation chemistry in White s total synthesis of avermectin Bia [13] is similar to Hanessian s synthesis of avermectin Bia (Scheme 12.9). Thus, the glycosidation of the... 

During the highly stereoselective total synthesis of epothilone B by J.D. White and co-workers, the stereochemistry of the alcohol portion of the macrolactone was established by applying Davis s oxaziridine oxidation of a sodium enolate. ... 

White, J.D., Tiller, T., Ohba, Y, Porter, W.J., Jackson, R.W., Wang, S., and Hanselmann, R., Total synthesis of rutamycin B via Suzuki macrocyclization, J. Chem. Soc., Chem. Commun., 19, 1998. Lafontaine, J.A., Provencal, D.P., Gardelli, C., and Leahy, J.W., The enantioselective total synthesis of the antitumor macrolide natural product rhizoxin D, Tetrahedron Lett., 40, 4145, 1999. 

Bhisutthibhan, J., Pan, X.-O., Hossler, P.A., Walker, D.J., Yowell, C.A., Carlton, J., Dame, J.B., and Meshnick, S.R. The plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin, /. Biol. Chem., 273,16192,1998. 21. Avery, M.A., Chong, W.K.M., and Jennings-White, C. Stereoselective total synthesis of (+)-artemisinin, the antimalarial constituent of Artemisia annua L., /. Am. Chem. Soc., 114,974,1992. Avery, M.A., Bonk, J.D., and Bupp, J. Radiolabeled antimalarials synthesis of 14C-artemisinin, /. Labelled Comp. Radiopharm., 38, 263, 1996. 

Heathcock C H, Graham S L, Pirrung M C, Plavac F, White C T 1983 The total synthesis of sesquiterpenes, 1970-1979. In ApSimon J (ed) SThe total synthesis of natural products, vol 5. Wiley-Interscience New York, 550 pp... 

The same conversion of 99 to 100 was also utilized by Fleet et al. [45] for the enantiospecific synthesis of (S)-quinuclidinol (103, Scheme 21). White et al. [46] employed the thermal rearrangement of the related vinyl ether 104 to aldehyde 105 for the total synthesis of monic acid C (106). 

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