Whey proteins opioid peptides

Pihlanto-Leppala, A. (2000). Bioactive peptides derived from bovine whey proteins Opioid and ace-inhibitory. Trends Food Sci. Technol. 11, 347-356. 

Paakkari, I., Jarvinen, A., Antila, P., Mattila, M.J., and Pihlanto-Leppala, A. 1994. Opioid effects of the milk whey-protein derived peptides a- and (3-lactorphin. In 3-Casomorphins and Related Peptides. Recent Development (V. Brand and H. Teschemacher, eds), pp. 33-37. VCH, Weinheim. 

Most of the known bioactive peptides derived from milk proteins are opioid peptides (Table V). Those derived from caseins are called casomorphins or casoxins, while those from whey proteins are lactorphins, lactoferroxins or serorphin. Major opioid peptides are fragments of (3-casein. 

Whey proteins contain opioid-like sequences, namely a-la (both bovine and human) f(50-53) and (3-1 g (bovine) f(102-105), in their primary structure. These peptides have been termed a- and (3-lactorphins (Chiba and Yoshikawa, 1986). Studies by Antila et al (1991) indicated that proteolysis of a-la with pepsin produces a-lactorphin, and that digestion of (3-lg with... 

Pihlanto-Leppala, A., Koskinen, P., Paakkari, I., Tupasela, T., and Korhonen, H. 1996. Opioid whey protein peptides obtained by membrane filtration. IDF Bull. 311, 36-38. 

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