Wheelwright

S. M. Wheelwright, Protein Purification Design and Scale-up of Downstream Processing, Hanser PubHshers, Munich, Germany, 1991, pp. 1—9, 61, 213—217. 

J. L. Ryan and E. J. Wheelwright, The Recovey, Purification, and Concentration of Plutonium byMnion Exchange in Nitric Mcid, HW-55893, General Electric... 

General Electric s Tollgate Process (Wheelwright and Clark, 1992). 

Wheelwright, S. C. and Clark, K. B. 1992 Revolutionising Product Development. NY The Free Press. 

Wheelwright, S. M., Designing downstream processes for large-scale protein purification, Bio/Technology, 5, 89, 1987. 

Jacobson, K.H., J.H.Clem, H.J.Wheelwright, Jr., W.E.Rinehart, and N.Mayes. 1955. The acute toxicity of the vapors of some methylated hydrazine derivatives. AMA Arch. Ind. Health 12 609-616. 

A general and most widely used method for the synthesis of PPV derivatives was introduced by Gilch and Wheelwright [33]. This method avoids high-temperature conditions and occurs through base-promoted 1,6-elimination of 1,4-/Ys(chloro/bromomethyl)bcnzcncs 7 (Scheme 2.4). For device applications, the as-synthesized PPV materials need to be soluble... 

SCHEME 2.4 General synthetic route or Gilch route to solution-processable PPV derivatives (From Gilch, H.G. and Wheelwright, W.L., J. Polym. Sci. Part A, 4, 1337, 1966.)... 

Roberts, F. P., Smith, F. M., Wheelwright, E. J. General Electric Co., Hanford Atomic Products Operation. Richmond, Washington 1962... 

Jacobson KH, Wheelwright HJ Jr, Clem JH, Shannon RN Studies on the toxicology of A/-nitrosodimethylamine vapor. AMA Arch Ind Health 12 617-622, 1955... 

Frequently however, enzymes found in the fermentation broth at the time of harvesting are quite different from the state in which they can be used as industrial biocatalysts, reagents in clinical chemistry or as therapeutic agents, The recovery of an enzyme from microbial culture, its concentration and purification will require careful and effective sequential operations, which ate called downstream processing (Wheelwright, 1989). 

Figure 5.19 General downstream process flow chart (adapted from Wheelwright, 1989).

N-[2-Hydroxyethyl]ethylenediaminetriacetic acid [150-39-0] M 278.3, m 212-214 (dec). Crystd from warm H2O, after filtering, by addition of 95% EtOH and allowing to cool. The crystals, collected on a sintered-glass funnel, were washed three times with cold absolute EtOH, then again crystd from H2O. After leaching with cold H2O, the crystals were dried at 100° under vacuum. [Spedding, Powell and Wheelwright JACS 78 34 1956]. 

Isenberg, N., Jackman, H. W., Investigation of Beckley Seam Coal Blended with Wheelwright Coal for Use in the Production of Metallurgical Coke, Inland Steel Co., East Chicago, 1945. 

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