What To Do When Constraints Are Not Satisfied

Struaures generated by distance geometry will not satisfy all distance and chiral constraints perfectly. Minor violations less than 0.5 A generally do not 

We thank Eric Martin for his helpful comments and careful reading of the text. The stereo triples were prepared with MidasPlus from the UCSF Computer Graphics Laboratory. 

Biophys., 19, 115 (1987). Distance Geometry and Related Methods for 

DSPACE, 1988. Infinity Systems, 14810 216th Ave NE, Woodinville, WA 98072. 

Wuthrich, Science, 243,45 (1989). Protein Structure Determination in Solution by Nuclear 

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