Welch potential

Baler, R., Welch, W.J., Voellmy, R. (1992). Heat shock gene regulation by nascent polypeptides and denatured proteins hsp70 as a potential autoregulatory factor. J. Cell. Biol. 117, 1151-1159. 

J. E. Freedman, B. Frei, G. Welch, J. Loscalzo, Glutathione Peroxidase Potentiates the Inhibition of Platelet Function by 5-Nitrosothiols ,./. Clin. Invest. 1995, 96, 394-400. 

Sierra V, Duttaroy A, Lutfy K, Candido J, Billings B, Zito SW, Yoburn BC. (1992). Potentiation of opioid analgesia by cocaine the role of spinal and supraspinal receptors. Life Sci. 50(8) 591-97. Smith FL, Cichewicz D, Martin ZL, Welch SP. (1998). The enhancement of morphine anti nociception in mice by delta9-tetrahydrocannabinol. Pharmacol Biochem Behav. 60(2) 559-66. 

Welch s stereoselective synthesis centered about the tandem conjugate addition of a methyl group and allylation to produce 583 (Scheme XLVI). A second methylation, combined with oxidation of the allyl sidechain, gave 584 which was successfully cyclized under Claisen conditions. Trapping of the enolate as in 585 permitted differentitation between the two potential ketone carbonyl groups. 

E.D. Hostetler, S.D. Jonson, M.J. Welch, J.A. Katzenellenbogen, Synthesis of 2-[F-18]fluoroestradiol, a potential diagnostic imaging agent for breast cancer Strategies to achieve nucleophilic substitution of an electron-rich aromatic ring with [F-18]F, J. Org. Chem. 64 (1999) 178-185. 

Stollenwerk, K.G. and Colman, J.A. (2003) Natural remediation potential of arsenic-contaminated ground water, in Arsenic in Ground Water (eds A.H. Welch and K.G. Stollenwerk), Kluwer Academic Publishers, Boston, pp. 351-80. 

C. David Gutsche is retired from the position of Robert A. Welch Professor at Texas Christian University. He is a pioneer in the use of calixarenes in systems designed to mimic enzymes. He has prepared numerous calixarene-type molecules, evaluated their host-guest binding abilities, and studied their catalytic potentials [48,49],... 

There are no cases of neurological effects in humans following parenteral exposure to barium compounds. In a few animal studies where barium chloride was injected intracerebroventricularly, insensitivity to pain occurred within minutes (Welch et al. 1983) followed by fatal convulsions if the dose was sufficient (Segreti et al. 1979 Welch et al. 1983). The significance of these data is difficult to assess since this unusual mode of entry would not occur in humans, and could be partially responsible for the rapid and extreme effects. Intraperitoneal injection of barium sulfate into mice produced an immediate increase in electroshock sensitivity followed by a decrease in sensitivity 24 hours later (Peyton and Borowitz 1978). These results are also difficult to assess in terms of effects observed in cases of human exposure, but suggest that barium in sufficient amounts may potentially influence brain function. 

Welch KD, Reilly TP, Bourdi M, et al. Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice. Chem Res Toxicol 2006 19 223-233. 

Lay and Skyllas-Kazacos were the first to describe a deposition from imidazolium-based tetrachloroaluminate ionic liquid [8], On glassy carbon, aluminum was deposited at —0.2 V (instead of—0.43 V for the pyridinium-based system of Osteryoung and Welch). Furthermore, they were able to show that the deposition process has complicated kinetics and is not simply controlled by diffusion. Using a tungsten electrode they were able to demonstrate in chronopotentiometric measurements that initially a potential of—0.65 V is necessary due to the nucleation process, but after reaching the barrier the potential drops below —0.2 V. 

Further comphcating the situation is a series of experiments which show that trivial culture conditions can profoundly affect metastatic potential of cells (Welch, 1997 and references therein). Examples of culture conditions that affect metastatic potential or metastasis-associated phenotypes include pH of the culture medium (Martinez-Zaguilan et al., 1998), the type of medium in which the cells are grown (Prezioso et al., 1993) and confluence (see Welch, 1997 and references therein). 

Maurer, D. K., and Welch, A. H., 1996, Hydrogeology and potential effects of changes in water use, Carson Desert Agricultural Area, Churchill County, Nevada U.S. Geological Survey Water Supply Paper 2436, 106 p. 

Welch, K. D., Reilly, T. P., Bourdi, M., Hays, T, Pise-Masison, C. A., Radonovich, M. E, Brady, J. N., Dix, D. J., Pohl, L. R. Genomic identification of potential risk factors during acetaminophen-induced Uver disease in susceptible and resistant strains of mice. Chem. Res. Toxicol. 2006,19, 223-233. 

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