Wedler-Boyer isotope exchange

STEREOCHEMICAL TERMINOLOGY, lURAC RECOMMENDATIONS WEDLER-BOYER ISOTOPE EXCHANGE PROTOCOL... 

ISOTOPE EXCHANGE AT EQUILIBRIUM WEDLER-BOYER TECHNIQUE CUMULATIVE INHIBITION UNCONSUMED SUBSTRATE CRYPTIC CATALYSIS BOROHYDRIDE REDUCTION ENZYME CASCADE KINETICS... 

This technique was initially developed by Boyer (1959) and subsequently considerably extended to involve rate measurement of loss, or exchange, of essentially il possible atoms or functional groups, the determination of kinetic isotope effects, the definition of stereochemical processes, and investigation of activators and inhibitors (Wedler Shalango, 1982 Wedler, 1995 Purich AUison, 2000). 

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