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Opinions differ widely on the subject of corporate websites. You can currently buy server disc space for HTML pages for a mere 5 US, or many providers include it with the basic account The main disadvantages are related to server functions, bandwidth and other offered services. 

Software Website Description of function and network algorithms used for gene network visualization References... 

We hope that this volume will be of use to not only neurochemists but also to many neuroscientists interested in the functioning of the nervous system and the effects of drugs on that functioning. We realize that some relevant techniques may well have been omitted in the volume, and would appreciate feedback from readers about techniques that should be included on the website and in future hard copies of this volume in the Handbook of Neurochemistry and Molecular Neurobiology. 

Physically, ion channels are tiny pores that stud the surface of all cells. The ion channels are important for, among other things, the function of muscles and the nervous system. These channels allow the passage of potassium, calcium, sodium, and chloride ions. Through a balance of electrical forces and chemical bonds, ion channels are specific for one ion for instance, a potassium ion channel will reject a sodium ion trying to enter its channel. An excellent visualization of the overall process is found at the website http //www. rockefeller.edu/pubinfo/howkion.html. It will be helpful to look at this website before going any further in the discussion. 

Consideration of the proposed indications for the candidate drug together with knowledge of its pharmacokinetics and metabolism in healthy volunteers will indicate whether specific studies in patients with impaired hepatic or renal function will be needed to be included in the Marketing Approval Application and NDA. Useful relevant guidelines are available on the FDA website and it is advisable to discuss proposals with the relevant regulatory authorities. The topic is considered in more detail in Chapter 5. 

Pharmaceutical nonactive excipients have long been applied in a variety of pharmaceutical dosage forms to provide a wide range of functional characteristics that facilitate the optimal delivery of a drug to achieve the desired therapeutic effects. Pharmaceutical excipients are inert materials with no adverse effects on the safety and efficacy of therapeutic products. The Food and Drug Administration (FDA) website (1) provides a database listing all the FDA-approved nonactive pharmaceutical excipients. This provides formulation scientists a useful reference for efficient choices of the suitable excipients for the desired formulations of drug. 

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