Warfarin preparative separation

A new brush-type CSP, the Whelk-0 1, was used by Blum et al. for the analytical and preparative-scale separations of racemic pharmaceutical compounds, including verapamil and ketoprofen. A comparison of LC and SFC revealed the superiority of SFC in terms of efficiency and speed of method development [50]. The Whelk-0 1 selector and its homologues have also been incorporated into polysiloxanes. The resulting polymers were coated on silica and thermally immobilized. Higher efficiencies were observed when these CSPs were used with sub- and supercritical fluids as eluents, and a greater number of compounds were resolved in SFC compared to LC. Compounds such as flurbiprofen, warfarin, and benzoin were enantioresolved with a modified CO, eluent [37]. 

DISPOSAL AND STORAGE METHODS prepare packages of warfarin in paper or other flammable materials and bum in a suitable combustion chamber dissolve in a flammable solvent, such as alcohol, and atomize in a suitable combusting chamber place in closed containers for storage should be kept well separated from oxidizing agents (nitrates, peroxides, etc.) should not be stored near combustible materials. 

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