Walsh, Christopher

Walsh, Christopher. Antibiotics Actions, Origins, Resistance. Herndon, VA ASM Press, 2003. 

Chen, Shoujun Lin, Chun-Hung Walsh, Christopher T. Coward, James K., Bioorg. Med. Chem. Lett., 1(5), 505-510(1997). 

Gertrude Walsh Robinson and Robert Robinson met as students in Chaim Weizmann s chemical laboratory at Manchester. Like Edith Hilda Usherwood Ingold and Christopher K. Ingold, the Robinsons co-authored some of their research. 

The most common posttranslational modifications, discussed in the following sections, include phosphorylation, sulfation, disulfide formation, N-methylation, O-methylation, S-methylation, N-acetylation, hydroxylation, glycosylation, ADP-ribosylation, prenylation, biotinylation, lipoylation, and phosphopan-tetheine tethering. Many of the posttranslational modifications are proven to be cross talks. Other modifications exist in a smaller extent and include oxidation of methionine, C-methylation, ubiquitylation, carboxylation, and amidation. These topics will not be covered in this chapter which is meant to focus primarily on the recent literature (2005-08). For a more complete coverage of all posttranslational modifications and earlier literature (up to 2005), the reader is referred to Professor Christopher T. Walsh s book Posttranslational Modification of Proteins Expanding Nature s Inventory ... 

We would like to acknowledge the work on posttranslational modification of proteins of those not cited in this chapter either due to the scope of the chapter or our ignorance. We thank Dr. Oleg V. Tsodikov for critical reading of the manuscript and help in the preparation of Figures 2, 6, and 9. SGT would also like to thank Professors John C. Vederas and Christopher T. Walsh for their invaluable support and mentorship. 

Steven D. Bruner received his B.S. degree from Boston College working in the laboratory of Marc Snapper. He received a Ph.D. degree in chemistry in 2000 from Harvard University under the direction of Professor Gregory Verdine. From 2000 to 2003, he was a Damon Runyon Cancer Research postdoctoral fellow in the laboratory of Professor Christopher Walsh at Harvard Medical School. In 2003, he joined the faculty in the Department of Chemistry at Boston College as an assistant professor. Research in his laboratory focuses on the use of structural biology and synthetic chemistry to characterize natural product biosynthetic enzymes. 

Our job in this chapter is to nnderstand what the important antibacterials are and how they work. If yon want the whole story in all its elegant scientific detail, Christopher Walsh has bronght it together in his book Antibiotics Actions, Origins, Resistance ... 

Figures 9 and 11 are reproduced from the Journal of the Chemical Society by permission of Sir Christopher Ingold, F.R.S., Professor A. D. Walsh, and the Chemical Society. We wish also to thank Dr. J. H. Callomon and Professor K. K. Innes for communicating results in advance of publication.

Neil Kelleher. Christopher Walsh Harvard Medical School... 

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