Wake shedding onset

The formation of an attached wake and the subsequent onset of wake shedding tend to be promoted by increasing oblateness (see Chapter 6) and by the tendency of surface-active contaminants to damp out internal circulation (see Chapter 5). Experiments have been conducted with dyes added to enable attached wakes and shedding phenomena to be visualized (H8, Ml, M2, S2) and wake volumes to be measured (H8, Y4) for drops and bubbles. Since dyes tend to be surface active, the results of these experiments are probably relevant... 

While other explanations have been proposed [e.g. (B6, El, H6)], secondary motions are most plausibly related to wake shedding. The onset of oscillations coincides with the onset of vortex shedding from the wake (El, E2, S5, W8). For high k or contaminated drops and bubbles, the onset of oscillations... 

The guanosine analog penciclovir is the active metabolite of famciclovir (see above). Topical application of 1% penciclovir cream is effective for the treatment of recurrent herpes labialis in immunocompetent adults (Table 49-1). When therapy was initiated within 1 hour after the onset of signs or symptoms and continued every 2 hours during waking hours for 4 days, treatment with topical penciclovir resulted in a shortening of the mean duration of lesions, lesion pain, and virus shedding by approximately one-half day compared with placebo. Side effects are uncommon. 

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