Vulnibactin

Fluvibactin (Fig. 13, 45) from Vibrio fluvialis (391) differs from agrobactin by replacement of spermidine by norspermidine. Also here the precursor with a free central NH group could be isolated. Vibriobactin from Vibrio cholerae (Fig. 14,46) contains two cyclized DHB-Thr substituents (129). Syntheses of agrobactin, fluvibactin and vibriobactin are published (26, 30, 308). In vulnibactin from Vibrio vulnificus (Fig. 14, 47) (264) two DHB groups are replaced by salicylic acid units. The precursor with a free central NH group was also found. 

Okujo N, Saito M, Yamamoto S, Yoshida T, Miyoshi S, Shinoda S (1994) Structure of Vulnibactin, a New Polyamine-containing Siderophore from Vibrio vulnificus. BioMetals 7 109... 

Bacterial siderophores are another class of widespread toxins produced by bacteria. On land, mycobactins and exophilins are the best-known representatives. Those found in the sea, aquachelins, marinobactins, anguibactin, vulnibactin, and aerobactin (Table 12.3.1) are amphiphilic. This is a property that has received great attention for drug delivery problems and in relation to recognition processes (Testa 2000), devising efBcient algorithms for computer calculation (Fisher 2000). 

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