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Volume change, tissue sample

Figure 6.4 Tissue parameter effects on microdialysis sampling extraction efficiency(EE) using the published Bungay et al. model.42 (a) Parameters in graph (a) denote changes with diffusion coefficients combined with the following parameters probe length, L, 0.3 cm inner radius, ri 0.021 cm outer radius, r0,0.025 cm cannula radius, rcannuia, 0.0175 cm tissue sample volume fraction, ( )s, 0.2 membrane diffusion coefficient, Dm, 0.2Dd tissue sample diffusion coefficient, Ds = Dd/2.25 K,.p 1.0 min-1, Km 0.1 min-1. In vitro simulation sets the external tissue resistance, Rc to a value of zero, (b) Variation in tissue sample volume fraction, <(is, with all parameters used. Dd —5 x 10 6 cm2/s. (c) Variation in sum of external rate constants. All other parameters are as in (a) with Dd— 5 x 10-6 cm2/s. Figure 6.4 Tissue parameter effects on microdialysis sampling extraction efficiency(EE) using the published Bungay et al. model.42 (a) Parameters in graph (a) denote changes with diffusion coefficients combined with the following parameters probe length, L, 0.3 cm inner radius, ri 0.021 cm outer radius, r0,0.025 cm cannula radius, rcannuia, 0.0175 cm tissue sample volume fraction, ( )s, 0.2 membrane diffusion coefficient, Dm, 0.2Dd tissue sample diffusion coefficient, Ds = Dd/2.25 K,.p 1.0 min-1, Km 0.1 min-1. In vitro simulation sets the external tissue resistance, Rc to a value of zero, (b) Variation in tissue sample volume fraction, <(is, with all parameters used. Dd —5 x 10 6 cm2/s. (c) Variation in sum of external rate constants. All other parameters are as in (a) with Dd— 5 x 10-6 cm2/s.
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