Volume bioadhesives

The polymer most commonly used to prepare brushes is poly (ethylene oxide) (PEO), which is alternatively called poly (ethylene glycol)(PEG). This is primarily because in an aqueous environment PEO molecules are highly mobile22 and strongly hydrated, attaining large exclusion volumes.23 Furthermore, PEO is biocompatible.24 Sometimes the role of polysaccharides to prevent bioadhesion is reported.25... 

When a dose form gets lodged, either a large volume of water or intake of food is required to shift the adhered tablet since water flows over the non-contact surface, and does not dislodge the zone of bioadhesion. 

---