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Vitamin aldehyde dehydrogenase

Free pyridoxal either leaves the cells or is oxidized to 4-pyridoxic acid by aldehyde dehydrogenase (which is present in all tissues) and also by hepatic and renal aldehyde oxidases. 4-Pyridoxic acid is actively secreted by the renal tubules, so measurement of the plasma concentration provides an index of renal function (Coburn et al., 2002). There is some evidence that oxidation to 4-pyridoxic acid increases with increasing age in elderly people, the plasma concentration of pyridoxal phosphate is lower, and that of 4-pyridoxic acid higher, than in younger subjects even when there is no evidence of impaired renal function (Bates et al., 1999b). Small amounts of pyridoxal and pyridox-amine are also excreted in the urine, although much of the active vitamin Be that is filtered in the glomerulus is reabsorbed in the kidney tubules. [Pg.235]

Non-cytochrome P450 enzymes may also be involved in oxidative reactions. One such enzyme is alcohol dehydrogenase whose substrates include vitamin A, ethanol, and ethylene glycol. Aldehyde dehydrogenase is another enzyme. Most reduction reactions also involve microsomal enzymes, with the exception of ketone reduction. Nitro compounds are reduced to amines and volatile anesthetics undergo dehalo-genation by microsomal enzymes. Hydrolysis reactions are involved in metabolism of compounds with amide bonds or ester linkages, as in the conversion of aspirin to salicylate (Brown, 2001). [Pg.551]

Cefoperazone Cefamandole Cefotetan Moxalactam Cefmetazole 102-156 min 30-50 min 3-4.6 h 114-150 min 72 min 3-4 mg/L One case of symptomatic hepatitis. All of these antibiotics have the /V-methyltetrazoletniol side chain which may inhibit aldehyde dehydrogenase to cause a disulfiramlike interaction with ethanol (see p 186) and coagulopathy (inhibition of vitamin K production). [Pg.82]

Dowling JE, Wald G (1960) The biological function of vitamin A acid. Proc Natl Acad Sci USA 46 587-608 McCaffery P, Tempst P, Lara G, Drager UC (1991) Aldehyde dehydrogenase is a positional marker in the retina. Development 112 693-702... [Pg.80]

Vitamin A is one of the isoprenoid lipids. It is closely related to carotene, its provitamin. The organism can produce vitamin A from carotene (cf. formula in Chapt. XIV-8). Two closely related substances, vitamin Ai and vitamin Aj, are distinguished. Vitamin A alcohol is easily dehydrogenated by the organism to give the aldehyde (by an alcohol dehydrogenase and NAD). Vitamin A aldehydes are components of visual purple (see Chapt. XIV-8). The role in the visual process is the only well-established biochemical fmction of vitamin A. [Pg.378]


See other pages where Vitamin aldehyde dehydrogenase is mentioned: [Pg.164]    [Pg.1333]    [Pg.1698]    [Pg.1019]    [Pg.1098]    [Pg.25]    [Pg.917]    [Pg.715]    [Pg.146]    [Pg.399]    [Pg.389]    [Pg.429]    [Pg.537]    [Pg.188]    [Pg.343]    [Pg.429]    [Pg.73]    [Pg.113]    [Pg.489]    [Pg.132]    [Pg.132]    [Pg.246]    [Pg.246]    [Pg.1081]    [Pg.703]    [Pg.245]    [Pg.22]    [Pg.311]    [Pg.494]    [Pg.427]   
See also in sourсe #XX -- [ Pg.235 ]

See also in sourсe #XX -- [ Pg.235 ]

See also in sourсe #XX -- [ Pg.235 ]




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Aldehyde dehydrogenase

Dehydrogenases aldehyde dehydrogenase

Vitamin aldehyde

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