Virus Sialidase Mechanism of Catalysis

The Influenza Virus Sialidase 1. Influenza Virus Sialidase Mechanism of Catalysis 

As mentioned, sialidase is believed to play two critical roles in the life cycle of the virus. At the molecular level, sialidase cleave terminal a-ketosidically linked sialic acid residues. The mechanism by which sialidases exert their hydrolytic activity remains an active field of research.34 37 In the absence of structural information, it was originally proposed that in the first step, the normally 2CS 

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