Virtual fragment linking approach

A similar virtual fragment linking approach validated across a variety of different target classes has also been reported [88]. A combination of virtual and experimental (NMR, biochemical) screening methods was employed to identify novel scaffolds for the design of kinase-targeted libraries [89]. 

Crisman TJ, Bender A, Milik M et al (2008) Virtual fragment linking an approach to identify potent binders from low affinity fragment hits. J Med Chem 51 2481-2491... 

Crisman, T.J., Bender, A., Milik, M., Jenkins, J.L., Scheiber, J., Sukuru, S.C., Fejzo, J., Hommel, U., Davies, J.W, and Click, M. (2008) Virtual fragment linking an approach to identify potent binders from low affinity fragment hits. Journal of Medicinal Chemistry, 51, 2481-2491. 

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