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Virtual fragment linking approach

A similar virtual fragment linking approach validated across a variety of different target classes has also been reported [88]. A combination of virtual and experimental (NMR, biochemical) screening methods was employed to identify novel scaffolds for the design of kinase-targeted libraries [89]. [Pg.20]

Crisman TJ, Bender A, Milik M et al (2008) Virtual fragment linking an approach to identify potent binders from low affinity fragment hits. J Med Chem 51 2481-2491... [Pg.222]

Crisman, T.J., Bender, A., Milik, M., Jenkins, J.L., Scheiber, J., Sukuru, S.C., Fejzo, J., Hommel, U., Davies, J.W, and Click, M. (2008) Virtual fragment linking an approach to identify potent binders from low affinity fragment hits. Journal of Medicinal Chemistry, 51, 2481-2491. [Pg.34]


See other pages where Virtual fragment linking approach is mentioned: [Pg.274]    [Pg.217]    [Pg.151]    [Pg.97]    [Pg.4]    [Pg.318]    [Pg.481]    [Pg.175]   
See also in sourсe #XX -- [ Pg.17 ]




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