Viridin antibiotics

A review on the stereochemistry of allylic pyrophosphate metabolism includes much information of relevance to the biosynthesis of triterpenoids. Lanosterol and various of its oxidized derivatives are efficiently utilized by Trichoderma viride for the production of the interesting antibiotic viridin (8). Sterol biosynthesis in the fungus Uromyces phaseoli proceeds by way of lanosterol, not cycloartenol. " When bramble [Rubus fruticosus (Rosaceae)] suspension cultures... 

Structural similarities between these oxazole containing 23-membered polyunsaturated macrocyclic lactones led to similar disconnection approaches providing entry to all members of this family of antibiotics. A retrosynthetic analysis for the synthesis of pristinamycin Ilg (virginiamycin M2) (34), griseo-viridin (35) and madumycin II (37) is depicted in Scheme 8 from which the key precursors (38), (39), (40), (41) and (42) have been identified for formation of the macrocycle [94, 95, 96]. 

Coumamidines )(1 and )(2, isomeric compounds isolated from an Actinomycete strain, have been characterized as the amino-sugar derivatives of a cinnamamide complex the same carbohydrate units are present in the related cinodines, which are glycocinnamoylspermidines (see Vol. 12, p. 153, ref. 63, structures (15) and (16)). Further work on the structure of the antibiotic complex spora-viridin has been reported (see Vol. 17, p. 181 Vol. 18, p. 186) six components have been characterized, differing in one unit of the... 

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