2-Vinylpyrazine with amines

A series of aminoethylpyrazines (C4H3N2CH2CH2N=) has been prepared by the reaction of vinylpyrazine with amines in the presence of methanolic acetic acid or metallic sodium as the catalyst (730) and likewise 2-[2 -(r -oxocyclohexan-2" yl)ethyl] pyrazine from vinylpyrazine and cyclohexanone (731). 

Ozonolysis of vinylpyrazine in methanol at — 30° furnishes pyrazine aldehyde in 73% yield.196 Vinylpyrazine undergoes a variety of addition reactions and pyrazylethyl derivatives of amines, ketones, ethyl phenyl acetate, phenylacetonitrile, and acetamide have been obtained.197-199 2-(2-Pyrazylethyl)cyclohexanone (42) has been prepared both by the condensation of vinylpyrazine with cyclohexanone in the presence of sodium metal and by interaction of vinylpyrazine with the pyrrolidine enamine of cyclohexanone followed by hydrolysis.200... 

A series of aminoethylpyrazines has been prepared in high yields by the reaction of 2-vinylpyrazine with ammonia or amines using methanolic acetic acid or metallic sodium as catalyst (730) 2-vinylpyrazine with acetamide and sodium at 120-130° gave 2-(2-acetamidoethyl)pyrazine (18) (731). 

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See also in sourсe #XX -- [ , ]

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