Vindoline analogues synthesis

Scheme 4.29. Synthesis of analogues of the indole alkaloid vindoline.

Kutney s work on the manipulation of the functional groups of vindoline, as a preliminary to the partial synthesis of vinblastine analogues, and the synthesis, in... 

Details have been published of the synthesis of analogues of vinblastine by Polonovski coupling of catharanthine N-oxide and various transformation products of vindoline, and a synthesis of catharinine (vinamidine) has been... 

The long series of experiments involving the synthesis of vinblastine analogues by the Polonovski coupling of catharanthine Nb-oxide derivatives with vindoline has culminated in the synthesis of vinblastine (290) itself, and this forms a fitting climax to any report on the past year s progress in indole alkaloid chemistry. 

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