Vindoline analogues

Scheme 4.29. Synthesis of analogues of the indole alkaloid vindoline.

Finally, a number of model vinblastine analogues, e.g. (209), have been synthesised by condensation of vindoline with an anilinoacrylate base related to vincadifformine, but lacking ring... 

Kutney s work on the manipulation of the functional groups of vindoline, as a preliminary to the partial synthesis of vinblastine analogues, and the synthesis, in... 

Details have been published of the synthesis of analogues of vinblastine by Polonovski coupling of catharanthine N-oxide and various transformation products of vindoline, and a synthesis of catharinine (vinamidine) has been... 

The long series of experiments involving the synthesis of vinblastine analogues by the Polonovski coupling of catharanthine Nb-oxide derivatives with vindoline has culminated in the synthesis of vinblastine (290) itself, and this forms a fitting climax to any report on the past year s progress in indole alkaloid chemistry. 

Two new analogues of catharanthine, 753 and 754, differing from catharanthine in the fusion of the indole ring to the non-aromatic portion of the iboga skeleton have been synthesized in racemic form and their reactivity toward coupling with vindoline examined. The [2,1] fused analogues (e.g., 753) were found to give low... 

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