Vincetoxicum officinale

Tylophora asthmatica, Cynanchum vincetoxkum, Pergularia pallida, Vincetoxicum officinale (Asclepiadaceae), Ficus septica (Moraceae)... 

Platonova et al. (6) have reported the isolation from Antitoxicum funebre Boiss. and Kotschy of the alkaloid antofine, C23H25O3N (mp 213°-215°), containing three methoxy groups. Pailer and Streicher (5) have suggested that their alkaloid A from Vincetoxicum officinale Moench could be identical with antofine. Both A and tylophorine were isolated from this plant. 

The aerial parts of Cynanchum vincetoxicum (L.) Pers. (Asclepiadaceae) contain three phenanthroindolizidine alkaloids, which have been shown to be tylophorine (34), 7-demethoxytylophorine (Alkaloid A, 35), and 7-demethoxy-demethyltylophorine (Alkaloid C, 36). The trimethoxy-base (35) has also been isolated, together with two unidentified alkaloids, from the dried roots of the same plant,and from Vincetoxicum officinale Moench., in which it occurs along with tylophorine. The early work on this trimethoxy-base indicated that it was either (35) or the 3,6,7-trimethoxy isomer, but this latter possibility has now been excluded. The n.m.r. spectrum did not allow a distinction to be made between (35) and the 3,6,7-trimethoxy analogue, hence the alkaloid was oxidised by mercuric acetate, and the immonium salt so obtained was... 

Two new secophenanthroindolizidine alkaloids, (13aR)-(—)-secoantofine (1278) and its (R)-(—)-6-0-desmethyl analog 1279, have been isolated from the leaves of Cynanchum vincetoxicum (L.) Pers. (= Vincetoxicum officinale. 

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