Vinca rosea plants

Vinca rosea plants Benzene Sulfuric acid... 

The alkaloid mixture from the extraction of Vinca rosea plants (as in vinblastine extraction) was chromatographed to give vincristine which was then converted to the sulfate, according to U.S. Patent 3,205,220. 

Vinca rosea plants. Both substances (Scheme 4) were incorporated specifically into loganin (10), ajmalicine (1), vindoline (4), and catharanthine (6) with the cis-compound (16) generally being more effective than the trans-isomer (15). The methoxycarbonyl groups of the isolated radioactive materials contained, in each case, ca. 40—48 % of the total activity showing the occurrence of extensive, if not complete, randomisation in the terminal units of (15) and (16). Thus, the equilibration process must involve introduction of oxygen at both C-9 and C-10 of geraniol or nerol. It was further shown that labelled (19), (20), and (21)... 

Macro-isolation and radiochemical dilution analysis based upon the incorporation of [5- H]loganin proved that both vincoside and isovincoside are present in Vinca rosea plants, and N-acetylvincoside was also isolated. Independently and simultaneously with the above work, strictosidine was isolated from Rhazya stricta, was proved to be present by dilution analysis in... 

Pharmacology of Vinca Alkaloids. —Vinca rosea plants have enjoyed a popular reputation in indigenous medicine in various parts of the world. They have been... 

First studies were undertaken with Periwinkle plants from Jamaica. The roots, stems, and leaves all contain active material the leaves contain the highest proportion of activity, but in the seeds almost no activity is found.Today we know that four of the pure alkaloids, crystallised from extracts of Vinca rosea plants, namely vinblastine [(169), = vincaleukoblastine)], vincristine [(170), = leurocristine], vinleurosine [= leurosine, (183)], and vinrosidine [= leurosidine, (181)] show good effects in suppression of tumour growth. In the last decade about fifty-five alkaloids have been found in Vinca rosea extracts and tested for their pharmacological effects. Besides the four mentioned none of the... 

This has been justified when radioactive tryptophan or tryptamine (decarboxytryptophan) were incorporated into several indole alkaloids ( 54-57).It has also been predicted that the non-tryptophan portions of these alkaloids are formed from two mevalonate units to afford a cyclopentane monoterpenoid precursor (58,59). This was proved upon feeding dl-[2- C]-mevalonic acid lactone, and sodium ( )-[2- C] mevalonate into vinca rosea plants and resulted in the isolation of radioactive vindoline, catharan-thine and ajmalicine ( 60-64). 

S- Hjjmevalonic acid lactone (58) to Vinca rosea plants. The deuterium-enrichment data for the deuteriovindoline were obtained by mass spectrometry and compared with those for unlabelled vindoline obtained under identical instrumental operating conditions. The data, as presented in Table 20, show that both deuteriums are present in M and in the fragments (57aX (S7d), and... 

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