Vinca major Periwinkle

Periwinkle Vinca major, vinca minor Cytotoxicity, renal failure, hepatic failure, neurological damage... 

Vinca minor/major periwinkle - Most water plants. 

Polydibromophenylene oxide Great Lakes SP-75 . See 1,2,5,6,9,10-Hexabromocyclododecane Great periwinkle extract. See Great periwinkle (Vinca major) extract Great periwinkle (Vinca major) extract CAS 90132-01-7 EINECS/ELINCS 290-418-1 Synonyms Great periwinkle extract Vinca major Vinca major extract Definition Extract of the great periwinkle, Vinca major... 

Vinca major Vinca major extract. See Great periwinkle (Vinca major) extract Vinca minor Vinca minor extract. See Periwinkle (Vinca minor) extract Vinclozolin... 

Vinblastine is an alkaloid derived from the periwinkle plant Vinca rosea. Its mechanism of action involves inhibition of tubulin polymerization, which disrupts assembly of microtubules, an important part of the cytoskeleton and the mitotic spindle. This inhibitory effect results in mitotic arrest in metaphase, bringing cell division to a halt, which then leads to cell death. Vinblastine and other vinca alkaloids are metabolized by the liver P450 system, and the majority of the drug is excreted in feces via the biliary system. As such, dose modification is required in the setting of liver dysfunction. The main adverse effects are outlined in Table 54-4, and they include nausea and vomiting, bone marrow suppression, and alopecia. This agent is also a potent vesicant, and care must be taken in its administration. It has clinical activity in the treatment of Hodgkin s... 

Vinca minor, V. major— the common periwinkles—contain numerous indole alkaloids including vincamine, majdine, majoridine. Their actions are antihaemorrhagic and astringent. Vinca spp. do not contain the antineoplastic alkaloids found in Cantharanthus (Wren 1988). 

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