Tuberous sclerosis vigabatrin

Vigabatrin is used as an adjunctive antiepileptic in patients with resistant partial epilepsy with or without secondary generalization, unresponsive to other therapy [2]. Nowadays, vigabatrin is rarely used in the treatment of partial seizures due to several irreversible visual field constrictions associated with its chronic use [57-62], It is regarded by many authorities as a drug of choice in infants with west syndrome (infantile spasms), particularly in cases associated with tuberous sclerosis [62],... 

Spence SJ, Nakagawa J, Sankar R, Shields WD. Phenobarbital interferes with the efficacy of vigabatrin in treating infantile spaans in patients with tuberous sclerosis. Epilepsia (2000) 41 (Suppl 7), 189. 

A 6-month-old boy with infantile spasms and tuberous sclerosis complex was treated with vigabatrin for 1 month. A routine follow-up MRI demonstrated asymptomatic diffusion abnormalities in bilateral thalami. Similar abnormalities were also identified in globi pallidi and brainstem. 

Thapa M, Khanna PC. Vigabatrin-associated diffusion MRI abnormalities in tuberous sclerosis. Pediatr Radiol 2010 40(Suppl 1) S153. 

---