Vestibular syndrome

Dimenhydrinate is an antiemetic especially usehil as an antinauseant in motion sickness, and for syndromes associated with vertigo such as Meniere s syndrome, radiation sickness, and vestibular dysfunction. It may produce mild drowsiness. It is FDA Category B for Pregnancy, and is available as an OTC preparation as well as by prescription. 

Usher syndrome is a deafness-blindness syndrome that is caused by mutations in a number of genes [29]. Usher syndrome is divided into three classes depending on the severity of the phenotype Usher I produces profound deafness and vestibular dysfunction, as well as adolescent blindness in Usher II, deafness is less profound. User III is less common in these patients, hearing and vision loss develop progressively, and vestibular dysfunction is variable. 

Hurle B, Ignatova E, Massironi SM, Mashimo T, Rios X., Thalmann I., Thalman R. Ornitz DM. 2003. Non-syndromic vestibular disorder with otoconial agenesis in Tilted/Mergulhador mice caused by mutations in otopetrin 1. Human Molecular Genetics 12 777-89. 

Of 20 patients with Dandy s syndrome, 15 had previously been treated with aminoglycosides (13 with gentamicin and 2 with streptomycin), of whom 10 had symptoms of pre-existing chronic nephrosis or transitory renal insufficiency. In aU 13 patients who had gentamicin, peripheral vestibular function was destroyed or severely damaged, whereas there was no hearing loss (31). 

Chronic toxic effects are dose related and typically involve cerebellar and vestibular functions (nystagmus and ataxia). Nausea, dizziness, diplopia, behavioral changes, gingival hyperplasia, hirsutism, hyperglycemia, osteomalacia, pancytopenia, and skin eruptions are reported complications of chronic therapy. Hypersensitivity (idiosyncratic) reactions, including hepatic necrosis and Stevens-Johnson syndrome, can occur and are potentially fatal. 

Roland, P. S., Haley, R, W Yellin. W Owens, K.. and Shoup, A. G. (2000). Vestibular dysfunction in Gulf War syndrome. Otolaryngol Head Neck Surg. 122,319-329. 

SCL26A4 (PDS) Pendrin Inner ear Thyroid Kidney Chloride Bloarbonate Hydroxide Formate Iodide 7q21-31 Pendred s syndrome Familial enlarged vestibular aqueduot with positive perohlorate test without goiter 274600... 

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