Vesicles magnetically sensitive

In the field of sensors, ion-binding block copolymers, which allow the formation of functionalized vesicles, could be of special interest. Vesicles sensitive to magnetic field were obtained from aqueous dispersion of hydrophobic iron oxide nanoparticles and block copolymers of PGA and PBD [272], Sachsenhofer and coworkers reported on the embedding of hydrophobic gold nanoparticles into PEO-PBD polymersomes [273]. Recently, polymer vesicles containing Ru(bpy )32+ units in the wall with a high potential for application in catalysis were introduced [274],... 

In an interesting variation of the technology. Law et al, (L2) described a liposome-based TSH assay in which the liposomal membrane surface contained covalently attached antibodies, and a modified membrane-impermeable acridinium ester derivative was encapsulated inside the vesicles. A normal sandwich assay was conducted using magnetic particles as the solid phase and antibody-sensitized liposomes as the label. The total assay time was 5 min, compared with the normal 2.5 hr, and showed superior sensitivity. 

Abbreviations CCK, cholecystokinin RNase. ribonuclease G-protein, guanine nucleotide binding protein GPCR, G-protein-coupled receptor. SDS sodium dodecylsulfate, CTAH. hexadecyltrimethyl ammonium hydroxide DMPC. di-myristoylphosphatidylcholine DPPC, di-palmitoylphosphatldylcholine CMC, critical micellar concentration SUV, small unilamellar vesicles CD, circular dichroism NMR, nuclear magnetic resonance hs-DC, high sensitivity differential scanning calorimetry IR-ATR, infrared attenuated total reflection spectroscopy NOE, nuclear Overhauser effect MD, molecular dynamics DMSO, dimethylsulfoxide TFE, trifluoroethanol for abbreviations of peptides see tables land 2, and fig. 11. 

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