Vernonia cinera

Examination of the Montenegro Achillea clavennae reveals the presence of three new chlorine-containing guaianolides 277-279 in addition to several known analogues (524). The first investigation of the Chinese medicinal plant Vernonia chinensis has uncovered the new chlorinated sesquiterpene lactones vemchinilides A (280), B (281), C (282) and E (283) (525). Vemchinilides B and E exhibit potent cytotoxic activity against the P-388 and A-549 cell lines. The structurally similar vemolide C (284) was found in the Cambodian traditional medicinal plant Vernonia cinera (fever, colic, malaria) (526). Indeed, vemolide C could be identical with vemchinilide A. 

Chea A, Hout S, Long C, Marcourt L, Faure R, Azas N, Elias R (2006) Antimalarial Activity of Sesquiterpene Lactones from Vernonia cinera. Chem Pharm Bull 54 1437... 

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