Veratridine binding

In summary, the computations based on veratridine binding exclusively to open channels whose availability determines the slow kinetics are only partially successful. Perhaps a better fit would require the inclusion of all possible transitions in Scheme 3 plus those not included like direct pathways, O -R etc. leaving too many degrees of freedom for a meaningful fit even under the constraint of microscopic reversibility. 

A cross-linked lipophilic derivative of dextran (Sephadex LH-20) has been reacted with veratridine via oxirane coupling and used to purify a veratridine-binding proteoglycolipid from rat. ° ... 

The effect of batrachotoxin on sodium fluxes has been studied extensively in neuroblastoma cells (see Table 5 at the end of this section for references). This system has been invaluable for delineating interactions of batrachotoxin with polypeptides. Such interactions involve allosteric modifications of the voltage-dependent sodium channel 57,59). It has been proposed that batrachotoxin binds selectively to an active state of the channel and that partial agonists such as aconitine and veratridine bind to both active and inactive states 168). Polypeptides such as scorpion toxin have been proposed to inhibit the conversion of active to inactive state, thereby decreasing the amount of inactive state available to the alkaloids. 

Veratridine is a complex lipophilic alkaloid that also binds to sodium channels, causing them to stay open and thereby disrupting the transmission of nerve action potential. It is found in the seeds of a member of the Liliaceae, Schoenocaulon... 

Veratridine Na+ channel of axonal Pyrethroids Binding site appears to... 

Deri Z, Adam-Vizi V (1993) Detection of intracellular free Na+ concentration of synaptosomes by a fluorescent indicator, Na+-binding benzofuran isophthalate the effect of veratridine, ouabain, and a-latrotoxin. J Neurochem 61 818-25... 

IV) ANTIARRHYTHMIC. It is a SMOOTH MUSCLE RELAXANT and coronary VASODILATOR. It can be used as an antihypertensive and antianginal. and in antimigraine prophylaxis, verapamil hydrochloride verapamil, veratridine is an alkaloid from Schoenocaulon officinale (Liliaceae), and is a neurotoxin and sodium-Channel ACTIVATOR that binds to Na -channels, leading to depolarization. It has similar but weaker actions to batrachotoxin. Vercyte pipobroman. 

The interaction of (+)-kavain with receptor site 1 of Na channels, which is the epitope of antagonists like saxitoxin and tetrodotoxin, and its influence on site 2, the binding site of agonists including veratridine, batrachotoxin, and aconitine, were investigated on cerebrocortical synaptosomes by radioligand-binding assays. 

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