Verapamil consciousness

Recently it was described that an 11-year-old boy who developed status epilepticus after a prolonged right-side simple partial motor seizure, which was unresponsive to long-term aggressive treatment with several AEDs [51]. The control of seizures was achieved at a plasma valproic acid level of 108 pg/ml, but electrical status epilepticus persisted, and the child remained comatose. On day 37, a treatment with verapamil (a calcium L-channel blocker) was started, and 1.5 h after the initiation of the infusion, the patient regained consciousness, breathed spontaneously, and the electrical status promptly disappeared. The authors suggested that verapamil, a... 

Edouard A Froidevaux R, Berdeaux A, Ahmad R, Samii K, Noviant Y. Bupivacaine accentuates the cardiovascular depressant effects of verapamil in conscious dogs. Eur J Anaesthe-520/(1987) 4, 249-59. 

Toxicity due to propafenone at what was expected to be a therapeutic dose occurred in a 72-year-old woman who developed impaired consciousness and hypotension. She was also taking verapamil, the dose of which had recently been increased to 80 mg tds. An electrocardiogram showed atrial fibrillation... 

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