Verapamil binding

Zhang, S., Zhou, Z., Gong, Q., Makielski, J.C. and January, C.T. (1999) Mechanism of block and identification of the verapamil binding domain to HERG potassium channels. Circulation Research, 84, 989-998. 

Figure 16.3 P-gp-verapamil binding inhibition pharmacophore (orange, ring aromatic feature green, hydrogen bond acceptor cyan, hydrophobic features). Reprinted with permission from ref. [45], Copyright 2002 American Society for Pharmacology and Experimental Therapeutics.

Figure 16.4 General pharmacophoric pattern of drugs at the verapamil-binding site of P-gp.

Garrigues et al. [49] characterized two different but partially overlapping P-gp pharmacophores. Initially, they determined affinities and mutual relationships from the changes in P-gp ATPase activity induced by a series of cyclic peptides, peptide-like compounds used alone or in combination. Because verapamil binding to P-gp... 

Reynolds, I.J., Gould, R.J., Snyder, S.H. pH] Verapamil binding sites in brain and skeletal muscle regulation by calcium, Eur. J. Pharmacol. 1983, 95, 319-321. 

Langguth, Int. J. Clin. Pharmacol. Ther., 38,168 (2000). Affinities at the Verapamil Binding Site of MDRl-Encoded P-Glycoprotein Drugs and Analogues, Stereoisomers and Metabolites. 

Mallik R, Yoo MJ, Chen S, Hage DS. Studies of verapamil binding to human serum albumin by high-performance affinity chromatography. J Chromatogr B 2008 876 69-75. 

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