Ventolin HFA

The effects of extreme temperatures on drug delivery of two albuterol sulfate hydrofluoroalkane (HFA) MDIs were evaluated. Three Proventil HFA and three Ventolin HFA MDIs were stored at room temperature and served as controls, while three of each product were placed in the trunk of a vehicle in Tuscon, Arizona. The temperature of the vehicle was monitored for six months. Product performance for each of the MDIs was evaluated at room temperature. An additional study was performed to investigate the performance of the two products when actuated at 4, 22, 47, and 60°C. Within one week of being placed in the test vehicle, all MDI... 

Ventolin HFA Albuterol sulfate None HFA 134a Suspension ... 

Tinkelman, D.G., E.R.Bleecker, J.Ramsdell, B.P.Ekholm, N.M.Klinger, G.L. Colice, and H.B.Slade. 1998. Proventil HFA and Ventolin have similar safety profiles during regular use. Chest 113 290-296. 

I Brand Name(s) AccuNeb, Proventil, Proventil HFA, Proventil Repetabs, Ventolin, Ventolin UFA, Ventolin Rotacaps, Volmax, VoSpire ER... 

Oleic acid Beclovent, Proventil, Proventil HFA, Vanceril, Ventolin, Xopenex HFA Dispersion Emulsification 0.267%... 

The vapor pressure and the design of the canister nozzle determine the aerosol jet and eventually impaction. Low vapor pressure increases drng delivery from a particular spacer due to a reduced jet and therefore rednced impaction. Airomir salbutamol pMDl containing HFA propellant delivered less drug as fine particles (MMAD < 5 pm) compared with the Ventolin salbutamol pMDI containing chloroflnorocarbon (CFC) propellant but a higher output from a spacer, probably due to a lower jet velocity (29). 

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