Vasospasm bromocriptine

Postural hypotension may occur, particularly at the initiation of therapy. Painless digital vasospasm is a dose-related complication of long-term treatment with the ergot derivatives (bromocriptine or pergolide). When cardiac arrhythmias occur, they are an indication for discontinuing treatment. Peripheral edema is sometimes problematic. Cardiac valvulopathy may occur with pergolide. 

Bromocriptine Activates dopamine D2 receptors Suppresses pituitary secretion of prolactin dopaminergic effects on CNS motor control and behavior Treatment of hyperprolactinemia and Parkinson s disease (see Chapter 28) Administered orally or vaginally Toxicity Gastrointestinal disturbances, orthostatic hypotension, headache, psychiatric disturbances, vasospasm and pulmonary infiltrates in high doses... 

A healthy postpartum woman taking bromocriptine developed very severe headache and marked hypertension after also taking phenylpropanolamine. Similarly another woman developed seizures with cerebral vasospasm, and a third developed a severe headache, hypertension and severe cardiac dysfunction after also taking isometheptene. A further patient taking bromocriptine developed psychosis when pseudoephedrine was added. 

Duvoisin, R. C. (1976) Digital vasospasm with bromocriptine. Lancet, ii, 204. 

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