Vasodilators classification

More recently, studies have been performed to determine the responsiveness of rat juxtameduUary afferent arterioles to receptor-selective P2- purinoceptor agonists [246]. Experiments were performed in vitro using the blood perfused juxtameduUary nephron technique, combined with videomicroscopy. The presence of multiple P2 receptors on juxtameduUary afferent arterioles and the classification of these receptors as members of the P2X- and P2Y2 (P2U)-receptor subtypes was demonstrated. In another study, the relative contributions of adenosine A1 and A2a receptors to the responsiveness of the renal microvasculature to adenosine was investigated [247]. The presence of adenosine A1 and A2a receptors on afferent and efferent arterioles of juxtameduUary nephrons was demonstrated. Also, adenosine A2a receptor-mediated vasodilation partially buffered adenosine-induced vasoconstriction in both pre- and postglomerular segments of the renal microvasculature. 

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