Vasodilator stimulated phosphoprotein VASP

Consensus docking sites for actin-based motihty, defined by the oligoproline modules in Listeria monocytogenes ActA surface protein and human platelet vasodilator-stimulated phosphoprotein (VASP). Analysis of... 

Chakrabarty et al. discovered that the host cell protein vasodilator-stimulated phosphoprotein (VASP) concentrates at the back of motile Listeria at the bacteria-tail junction. VASP docks onto the surface of Listeria by binding to the oligoproline sequences of ActA concentrated on the rearward pole of moving bacteria. In uninfected host cells, VASP is normally found in focal con-... 

Fig. 4. The structure of human vasodilator-stimulated phosphoprotein (VASP) is that of a parallel chain, four-stranded coiled-coil (Kuhnel et al., 2004). The sequence contains a pair of 15-residue repeats, resulting in the formation of a right-handed coiled coil with a pitch length of 18.5 nm, a value directly comparable to that seen in left-handed two-stranded coiled coils. Figure courtesy of Sergei Strelkov.

PGI2 exerts its inhibitory activity by increasing cyclic adenosine monophosphate (cAMP) formation via adenylate cyclase, which stimulates phosphorylation of a cytoskeleton integrin protein-associated vasodilator-stimulated phosphoprotein (VASP), which prevents GPIIb Ilia activation (16). 

Aszodi A, Pfeifer A, Ahmad M et al. (1999) The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP-and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function. EMVBO J 18 37—48... 

Butt, E., Abel, K., Krieger, M., Palm, D., Hoppe, V., Hoppe, J., Walter, U. (1994). cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets. J. Biol. Chem. 

Hiittelmaier S, Harbeck B, Steffens O, Messerschmidt T, Illenberger S, Jockusch BM (1999) Characterization of the actin binding properties of the vasodilator-stimulated phosphoprotein VASP. FEBS Lett 451 68-74 Hussey PJ, Ketelaar T, Decks MJ (2006) Control of the actin cytoskeleton in plant cell growth. Annu Rev Plant Biol 57 109-125... 

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